NUTRITIONAL BIOCHEMISTRY Please read & check the attached file before sending your offer! 1- 1900 words. 2- Word count on the cover page of the report. 3- References list and the te

NUTRITIONAL BIOCHEMISTRY

1. 1900 words.

2. Word count on the cover page of the report.

3. References list and the text in any legends to diagrams should be excluded from word count.

4. Referencing style: Harvard or Vancouver style

5. No Plagiarism

Formatting

• Font: Use either Arial or Times New Roman

• Font size: 11 or 12 point size.

• Line spacing: Use 2.0 or no less than 1.5

• Margins: Use default margin or no less than 2.5 cm

• Preferably use left and right justified text

• All pages should be numbered

Answer all questions in Part A and in Part B. You may include diagrams but do not copy and paste figures from the internet.

Part A (50% of total mark)

Metabolism in the human body is a complex process that involves coordination between tissues and interactions between macronutrients. The liver plays a central role in the metabolism of macronutrients.

1. Discuss how carbohydrates, fats and proteins are metabolised and regulated by the liver

(650 words) (35 marks).

1. Discuss how liver metabolism influences the metabolism and storage of fuels in other tissues (350 words) (10 marks)

Part B (50% of total mark) (300 words per question)

1. 1. a) Alex goes out and has a burger meal with friends and then stops at a pub where she has two cocktails each containing 35 mL of gin. Explain how Alex’s body processes the alcohol in the drinks (10 marks).

      1. Explain how vitamin E can behave as an antioxidant inside the human body (5 marks):

   2. a) Describe how vitamin D3 is produced in humans and explain how and where in the body it is synthesised, stored, activated and deactivated with reference to the key metabolic transformations it undergoes during these processes (10 marks).

      1. Briefly discuss the current Government recommendations for achieving vitamin D sufficiency in the UK population. (5 marks)

   3. a) Explain how dietary iron deficiency can lead to microcytic anaemia (6 marks)

      1. Explain why plasma ferritin is a poor biomarker of iron status in infection (3 marks)

      2. Discuss how iron differentially regulates the expression of transferrin receptor and ferritin via iron regulatory proteins (IRPs) (6 marks)

Notes:

Provide separate answers for each of the above questions. Number your answers so we know which section relates to which question.

You may include up to three diagrams but do not simply include detailed metabolic pathways as we will be looking for your interpretation and understanding of metabolism. Do not simply copy figures from the internet. Include a legend containing a brief explanation of any figures you do include.

You should cite any textbooks and journals you refer to and include a list of references at the end. Drawing upon scientific literature beyond the course textbooks is essential for high-scoring reports.

Suggested reading:

Bender D. Introduction to Nutrition and Metabolism (5th ed)

Frayn K. Metabolic Regulation, a Human Perspective (4th ed) Wiley Blackwell

Geissler C. & Powers H. Human Nutrition (13th ed) Churchill Livingstone.

You can refer to http://www.nhs.uk/Livewell/Goodfood/Pages/reference-intakes-RI-guideline-dailyamounts-GDA.aspx for information on reference intakes and to the Eatwell Guide and Government dietary recommendations available at https://www.gov.uk/government/publications/the-eatwellguide.

NHS website for England - NHS