Assignment 2: Article Critique
3 /1 9/2 017 @ W ald en U niv ers ity L ib ra ry h ttp ://e ds.b .e bscohost.c om .e zp.w ald enulib ra ry .o rg /e ds/d eliv ery ?sid = dfb 9d3529 7fa 4 9148 891b 714d5160941% 40sessio nm gr1 02& vid = 2& hid = 108& R etu rn U rl= h … 1 /3 T it le : A uth ors :
A ddre ss:
S ourc e: N LM T it le A bbre via tio n: P ag e C ount: P ublis h er: I S SN : L an guag e:
K eyw ord s:
A bstr a ct: R eco rd : 1 D eve lo pin g b io m ark e rs in m ood d is o rd ers r e se arc h th ro ugh th e u se o f r a pid ‐ actin g a ntid epre ssa nts .
N ic iu , M ark J .. E xp erim enta l T hera peutic s & P ath ophysio lo gy B ra nch , I n tr a m ura l R ese arc h P ro gra m , N atio nal In stit u te o f M enta l H ealt h , N atio nal In stit u te s o f H ealt h , B eth esd a, M D, U S M ath ew s, D anie l C .. L undbeck, L LC , D eerfie ld , IL , U S N ugent, A llis o n C ., O RCID 0 0000 0032 5692 480. E xp erim enta l T hera peutic s & P ath ophysio lo gy B ra nch , In tr a m ura l R ese arc h P ro gra m , N atio nal In stit u te o f M enta l H ealt h , N atio nal In stit u te s o f H ealt h , B eth esd a, M D, U S I o nescu , D aw n F .. E xp erim enta l T hera peutic s & P ath ophysio lo gy B ra nch , I n tr a m ura l R ese arc h P ro gra m , N atio nal In stit u te o f M enta l H ealt h , N atio nal In stit u te s o f H ealt h , B eth esd a, M D, U S F ure y, M aura L .. E xp erim enta l T hera peutic s & P ath ophysio lo gy B ra nch , I n tr a m ura l R ese arc h P ro gra m , N atio nal In stit u te o f M enta l H ealt h , N atio nal In stit u te s o f H ealt h , B eth esd a, M D, U S R ic h ard s, E ric a M .. E xp erim enta l T hera peutic s & P ath ophysio lo gy B ra nch , In tr a m ura l R ese arc h P ro gra m , N atio nal In stit u te o f M enta l H ealt h , N atio nal In stit u te s o f H ealt h , B eth esd a, M D, U S M ach ado ‐ Vie ir a , R odrig o. E xp erim enta l T hera peutic s & P ath ophysio lo gy B ra nch , In tr a m ura l R ese arc h P ro gra m , N atio nal In stit u te o f M enta l H ealt h , N atio nal In stit u te s o f H ealt h , B eth esd a, M D, U S Z ara te , C arlo s A . J r.. E xp erim enta l T hera p eutic s & P ath ophysio lo gy B ra nch , In tr a m ura l R ese arc h P ro gra m , N atio nal In stit u te o f M enta l H ealt h , N atio nal In stit u te s o f H ealt h , B eth esd a, M D, U S, z a ra te c@ mail. n ih .g ov Z ara te , C arlo s A . J r., E xp erim enta l T hera p eutic s & P ath ophysio lo gy B ra nch , In tr a m ura l R ese arc h P ro gra m , N atio nal In stit u te o f M enta l H ealt h , N atio nal In stit u te s o f H ealt h , 1 0 C ente r D riv e , M SC 1 282, B uild in g 1 0C RC, R oom 7 5 342, B eth esd a, M D, U S, 2 0892, z a ra te c@ mail. n ih .g ov D epre ssio n a nd A nxie ty , V ol 3 1(4 ), A pr, 2 014. p p. 2 973 07.
D epre ss A nxie ty 1 1 U S : J o hn W ile y & S ons 1 0914 269 ( P rin t) 1 5206 394 ( E le ctr o nic ) E nglis h m ood d is o rd ers , a ntid epre ssa nts , b io m ark e rs , tr e atm ent r e sp onse s, n euro im agin g A n im pedim ent to p ro gre ss in m ood d is o rd ers r e se arc h is th e la ck o f a naly tic a lly v a lid a nd q ualif ie d d ia gnostic a nd tr e atm ent b io m ark e rs .
C onsis te nt w it h th e N atio nal In stit u te o f M enta l H ealt h ( N IM H)'s R ese arc h D om ain C rit e ria ( R DoC ) in it ia tiv e , th e la ck o f d ia gnostic 3 /1 9/2 017 @ W ald en U niv ers ity L ib ra ry h ttp ://e ds.b .e bscohost.c om .e zp.w ald enulib ra ry .o rg /e ds/d eliv ery ?sid = dfb 9d3529 7fa 4 9148 891b 714d5160941% 40sessio nm gr1 02& vid = 2& hid = 108& R etu rn U rl= h … 2 /3 D ocu m en t T y p e: S ubje cts : M ed ic al S ubje ct H ead in gs ( M eS H ): P sycIN FO C la ssif ic atio n: P opula tio n: G ra n t S ponso rs h ip : b io m ark e rs h as p re clu ded u s fr o m m ovin g a w ay fr o m a p ure ly s u bje ctiv e ( s ym pto m ‐ base d) to w ard a m ore o bje ctiv e d ia gnostic s yste m . In a ddit io n, t r e atm ent r e sp onse b io m ark e rs in m ood d is o rd ers w ould fa cilit a te d ru g d eve lo pm ent a nd m ove b eyo nd tr ia l ‐ and ‐ erro r to w ard m ore p ers o naliz e d t r e atm ents . A s s u ch , b io m ark e rs id entif ie d e arly in th e p ath ophysio lo gic a l p ro ce ss a re p ro xim al b io m ark e rs ( ta rg et e ngagem ent) , w hile th ose o ccu rrin g la te r in th e d is e ase p ro ce ss a re d is ta l ( d is e ase p ath w ay c o m ponents ). O ne s tr a te gy to a ch ie ve th is g oal in b io m ark e r d eve lo pm ent i s to in cre ase e ff o rts a t th e in it ia l p hase s o f b io m ark e r d eve lo pm ent ( i. e .
e xp lo ra tio n a nd v a lid atio n) a t s in gle s it e s w it h th e c a pabilit y o f in te gra tin g m ult im odal a ppro ach es a cro ss a b io lo gic a l s yste m s le ve l. S ubse quently , r e su lt a nt p uta tiv e b io m ark e rs c o uld th en u nderg o c h ara cte riz a tio n a nd s u rro gacy a s th ese la tte r p hase s r e quir e m ult is it e c o lla bora tiv e e ff o rts .
W e h ave u se d m ult im odal a ppro ach es – g enetic s, p ro te om ic s/m eta bolo m ic s, p erip hera l m easu re s, m ult im odal n euro im agin g, n euro psych opharm aco lo gic a l c h alle nge p ara dig m s a nd c lin ic a l p re dic to rs – to e xp lo re p ote ntia l p re dic to r a nd m edia to r/m odera to r b io m ark e rs o f th e r a pid ‐ actin g a ntid epre ssa nts k e ta m in e a nd s co pola m in e. T hese e xp lo ra to ry b io m ark e rs m ay th en b e u se d fo r a p rio ri s tr a tif ic a tio n in la rg er m ult is it e c o ntr o lle d s tu die s d urin g th e v a lid atio n a nd c h ara cte riz a tio n p hase s w it h th e u lt im ate g oal o f s u rro gacy. In s u m , th e c o m bin atio n o f ta rg et e ngagem ent a nd w ell ‐ qualif ie d d is e ase ‐ re la te d m easu re s a re c ru cia l to im pro ve o ur p ath ophysio lo gic a l u nders ta ndin g, p ers o naliz e tr e atm ent s e le ctio n, a nd e xp and o ur a rm am enta riu m o f n ove l t h era peutic s. ( P sycIN FO D ata base R eco rd ( c ) 2 016 A PA , a ll r ig hts r e se rv e d) J o urn al A rtic le * A ff e ctiv e D is o rd ers ; * A ntid epre ssa nt D ru gs; * B io lo gic a l M ark e rs ; * N euro im agin g; T re atm ent O utc o m es A nalg esic s; A ntid epre ssiv e A gents ; B io m ark e rs ; C holin erg ic A nta gonis ts ; G enom ic s; H um ans; K eta m in e; M eta bolo m ic s; M ood D is o rd ers ; M ult im odal Im agin g; N euro im agin g; R ese arc h D esig n; S co pola m in e H yd ro bro m id e M edic a l T re atm ent o f P hysic a l Illn ess ( 3 3 63) H um an S ponso r: N atio nal In stit u te s o f H ealt h , N atio nal In stit u te o f M enta l H ealt h , I n tr a m ura l R ese arc h P ro gra m R ecip ie nts : N o r e cip ie nt in dic a te d S ponso r: D epartm ent o f H ealt h & H um an S erv ic e s R ecip ie nts : N o r e cip ie nt in dic a te d S ponso r: N atio nal A llia nce fo r R ese arc h o n S ch iz o phre nia a nd D epre ssio n O th er D eta ils : In dependent In ve stig ato r R ecip ie nts : N o r e cip ie nt in dic a te d 3 /1 9/2 017 @ W ald en U niv ers ity L ib ra ry h ttp ://e ds.b .e bscohost.c om .e zp.w ald enulib ra ry .o rg /e ds/d eliv ery ?sid = dfb 9d3529 7fa 4 9148 891b 714d5160941% 40sessio nm gr1 02& vid = 2& hid = 108& R etu rn U rl= h … 3 /3 F orm at C overe d :
P ublic atio n T y p e: P ublic atio n H is to ry : R ele ase D ate : C opyrig ht: D ig it a l O bje ct Id en tif ie r: P M ID : A ccessio n N um ber: N um ber o f C it a tio ns in S ourc e: D ata b ase: S ponso r: S ponso r n am e n ot in clu ded O th er D eta ils : B ra in & B ehavio r M ood D is o rd ers R ese arc h A w ard R ecip ie nts : Z ara te , C arlo s A . J r.
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