Discussion- 1 page

RUNNING HEAD: Annotated Bibliography 1

References

1. Benesch, M. G., Ko, Y. M., McMullen, T. P., & Brindley, D. N. (2014). Autotaxin in the crosshairs: taking aim at cancer and other inflammatory conditions. FEBS letters, 588(16), 2712-2727.

The authors of this book look into how autotoxin, a secreted enzyme which is used in production of extracellular lysophosphatidate from lysophosphatidylcholine and how it can be used in combating cancer and other conditions of inflammatory nature. The authors take us through how different autotoxin forms within the body as well as others induced through medical procedures can play vital roles in remodeling of tissues ad healing wounds. Through this process there is drive for inflammatory conditions such as asthma, cancer and colitis. Lysophosphatidate when signaled helps in promoting resistance to radiotherapy and chemotherapy. The book performs a review, analysis and summary of existing and current knowledge on disease processes which are autotoxin-mediated, with cancer being among them and performs discussions on autotoxin-targeting series and the developments seen in the advancements. The authors are geared to providing new insights to using autotoxins as mediators of inflammatory conditions in a tumor micro-environment where cancer progression is supported and there is resistance of therapy.

1. Couzin-Frankel, J. (2013). Cancer immunotherapy.

Immunotherapy was chosen by scientists as a breakthrough to cancer treatment. This strategy harnesses the immune system of the body for combating tutors. Researchers, scientists and professionals in the field of medicine have sought a way to ensure this process works for cancerous patients. Oncologists have identified that the efforts are giving results with two different techniques being used in offering patients help with their cancerous conditions. One of the approaches makes use of antibodies which release T cells and therefore gives them the power to tackle tumors. The other is involving of genetical modification of the T cells of an individual externally to help them be in a better position to battle cancer and then they are reinfused. The authors have showed how the techniques work in some cases however with their advanced research they hope to give cancer patents better hope for brighter futures.

1. Nelson, H. D., Smith, M. B., Griffin, J. C., & Fu, R. (2013). Use of medications to reduce risk for primary breast cancer: a systematic review for the US Preventive Services Task Force. Annals of internal medicine, 158(8), 604-614.

The authors give an approach on how medication can be used as an approach for reduction of risk factors which can lead to breast cancer. Medication is recommended for use by women who are at increased risk however their usage is low. This book was written in order to get updates on evidences showing effectiveness of and the adverse effects resulting from use of medication in making attempts to reduce occurrence of breast cancer. Also, the book was written for purposes of identification of methods important for identification of women who are at a higher exposure risk of getting breast cancer. Data was extracted from different sources and synthesized in order to come up with the conclusions.

1. Trotti, A., Byhardt, R., Stetz, J., Gwede, C., Corn, B., Fu, K., ... & Shipley, W. (2000). Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy. International Journal of Radiation Oncology* Biology* Physics, 47(1), 13-47.

The authors in this book looked into various toxicity criteria in order to have a better understanding of cancer, its occurrence and how to treat it. The authors identified that cancerous cells can multiply and reoccur successively therefore the need for continuous successive treatment. They have also identified that some forms of cancer reoccur frequently and therefore the need for regular checking to be performed. Also, there is a study of possible risk factors, how they can be mitigated as well as identification of control conditions to control the regeneration and reoccurrence of cancerous cells. Different forms of cancer have different forms of detection through different types of testing. There is importance in one learning the type of cancer they have, how to get checked and other steps to mitigate further effects.