Looking for a tutor to assist me understanding the probabilities of time and survival rates. Paperwork attached

Epidemiology Methods

Book exercises: Measures of Occurrence and Association

NOTE: Show work for better interpretation.

Incidence Density

A hypothetical cohort study was conducted to look at survival after being diagnosed with breast cancer. Ten participants were followed for 2 years, resulting in the following table:

Follow-up Time (Months)

Event

2

Censored

6

Death

8

Death

14

Censored

15

Death

19

Death

21

Censored

24

Followed until end of study period

24

Followed until end of study period

24

Followed until end of study period

  1. What is the cumulative survival probability at the end of the follow-up period?

  1. Using the same data, calculate the overall death rate per 100 person-years.



  1. Calculate the rates separately for each of the 2 years of follow-up.



  1. Based on the information above, is it appropriate to report an overall 2-year death rate for this study? Why or why not?


Attributable Risk

A hypothetical cohort study looked at the association between family history and the risk of developing Parkinson’s disease. The results were as follows:

Parkinson’s Disease

No Parkinson’s Disease

Totals

Incidence of Parkinson’s

Family History

50

150

200

250 per 1,000

No Family History

50

750

800

62.5 per 1,000

  1. Calculate the attributable risk for Alzheimer’s disease due to family history. Interpret the calculation in words.




  1. Assume the prevalence of family history in the general population is 10%. Calculate the population attributable risk and interpret it in words.

  1. Now assume the prevalence of family history in the general population is 25%. What effect does this change have on the estimate of the population attributable risk? Discuss the relationship between the population prevalence of exposure and the population attributable risk. Why is it important to understand this relationship as a public health professional?

2