All of the following statements about growth hormone are true, EXCEPT:

All of the following statements about growth hormone are true, EXCEPT:

a) It may stimulate the synthesis or release of somatomedins

b) Low levels of insulin-like growth factor (IGF)-1 are associated with dwarfism

c) Hypersecretion can result in acromegaly

d) It is contraindicated in subjects with closed epiphyses