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Compose a 500 words essay on Checkpoint kinases (CHK2). Needs to be plagiarism free!According to the figure 3,the list indicates several transcripts from the same gene and different SNP effect.The rea
Compose a 500 words essay on Checkpoint kinases (CHK2). Needs to be plagiarism free!
According to the figure 3,the list indicates several transcripts from the same gene and different SNP effect.The reason to this is as shown in the figure 4 which has all the splice variants(27) of the CHK 2 gene.In the figure 4 ‘‘protein coding” implies that the transcript encodes a CHK 2 protein variant.
The reason why we see GAA/GAG yet the SNP was T/C change is that it is a silent mutation whereby GAA and GAG code for glutamic acid.Also the reason why the new C(GAG) is more frequent in some populations is because there was a successful mutation.
Basing on the analysis above, we can see that the SNP resulted to silent mutation. By definition, silent mutation is a type of a point mutation that leads to a codon which codes for different or same amino acid but without any functional change in that particular protein. Hence, it does not cause change in the sequence of amino acid, thus, the protein will remain functional. In this regard, they are taken to be evolutionarily neutral. In relation to this, the CHK2 SNP (T/C) is considered to be silent mutation because the sequence of the protein which is GAA/GAG remains unchanged. Therefore, its function remains the same. It can therefore influence splicing because the nucleotides sequence has been altered.
While most of the RNA transcripts from protein encoding genes of the human genome are related to physiological splicing, pathological splicing has been found in cancer tissue (Berge et al, 2010). The Chk2 is known to be a multi-organ susceptible gene that provides a barrier to tumorigenesis to maintain a genomic stability, and this gene has found mutated in both hereditary and somatic cancer. Despite the fact that other genes’ alternative splice forms have been found to have a negative impact on the wild type molecules, the CHK2 splice protein variants function is still not clear(Berge et al, 2010).For instance, the mRNA splice variants for Chk2 gene
