ficking motifs important in this discussion? also why is codon harmonization important? Why are the researchers concerned with the membrane potential?...

Why are trafficking motifs important in this discussion? also why is codon harmonization important?Why are the researchers concerned with the membrane potential?How does verapamil work to treat resistant malaria? Explain the mechanism.Why pH is so important in this case?based on the first 4 pages of this article, answer the mentioned questions:https://www.unifr.ch/biochem/assets/files/teaching/seebeck/Martin_09.pdf