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Hi, need to submit a 1750 words paper on the topic Chlamydia Pneumoniae Pathogen.
Hi, need to submit a 1750 words paper on the topic Chlamydia Pneumoniae Pathogen. Chlamydia pneumonia is structured in two types the infectious, non replicating elementary body (EB) and the noninfectious actively replicating reticulate body (RB). The EB and RB alternate in the development of the infectious cycle. EBs are different morphologically to the RBs as they represent different adaptations to the extracellular environment and to the intracellular one correspondingly. The particle that has been infected is steady in the extracellular environment is the EB it enters the host cell, multiply and disseminate in the host extracellular environment. The pathogen completes the developmental cycle by alternating its form morphology and function.
The outer membrane of Chlamydia pneumonia comprises of lipopolysaccharides (LPS) and heat-shock proteins (HSP). The LPS is composed of KDO (2-keto-3-deoxycholate) units with the linear trisaccharide a-KDO-(2-8)-a-KDO-(2-4)-a-Kdo. The MOMP is detectable by monoclonal antibodies, thus under these conditions that are persistence-inducing, the chlamydia Hsp60 looks as if it is extremely upregulated. Chlamydia Hsp60 has proinflammatory effects by the mononuclear leukocytes being directly activated that are used for intervening in the inflammatory response. The persistence of the pathogen is categorized by morphologically aberrant RBs that do not undergo cytokinesis thus form a third chlamydial type called noninfectious, nonreplicating persistence body (PB). Upon the removal of the stress factor from the body’s immune system, then PB re-enters the productive life cycle (Murphy, 2011).
The EB adhering to the target cell membrane initiates penetration as it is dense and not big. It also has a firm cell wall that the SS bonds give and two other major outer membrane proteins known as the CRPs. Environmental factors that favor survival in the extracellular environment after cell lysis and switching from one cell or one host to another make EB be resistant. .
