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Hi, need to submit a 2250 words paper on the topic Mechanism Cellular Recognition and Entry by Porcine Circovirus.
Hi, need to submit a 2250 words paper on the topic Mechanism Cellular Recognition and Entry by Porcine Circovirus. Porcine circovirus disease (PCVD) is a viral disease, which attacks pigs and has recently been a problem in the US and many parts of China. The viral exists in two types 1, and 2, however, the Porcine Circovirus Type (PCV2) is the common one, which shows clinical signs when it infects swine. Evidently, PCV2 is spread all over the world and causes a lot of problems in domestic swine production. The disease exhibits so many syndromes, which are collectively known as porcine circovirus diseases (Murphy 400). The most relevant ones are Postweaning multisystemic wasting syndrome (PMWS), reproductive disorders, and porcine nephropathy and dermatitis syndromes. Nonetheless, only PMWS has proved to be the most severe and highly affect swine production and is common in pigs at nursery or those that are fattening. Among the clinical signs, wasting is the most prominent (Morilla, Kyoung-Jin, and Jeffrey 284-286).
This is observed under a cryo-electron microscope (cryo-EM) to reconstruct a full length of the virus particles at a resolution of 9.6-Å resolution. The image reveals features such as strands, binding sites, and capsid epitopes visualization (Mettenleiter, Thomas, and Francisco 123).
PCV1 and PCV2 are found in the Circoviridae family, which is composed of viruses with a single-strand DNA genome that is circular and to the generic members called Circovirus. However, other known generic names include pigeon circovirus, canary circovirus, goose circovirus, and feather, and beak disease virus. Several species result in lymphoid depletion within the infected hosts, although, some cause subclinical infection. Again, the family members are small and non-enveloped and have a capsid that is icosahedral (Cann 302).
There are strains type 1 (PCV1) and type 2 (PCV2). however, PCAD is caused by PCV2. PCV-1 was discovered in 1974, though it has not caused any notable disease in pigs.
