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Hi, need to submit a 4000 words essay on the topic Case study reflection 2 pages per case 8 total.tudy of metformin-associated lactic acidosis-MALA, in which the interactions of drug that is, orlistat
Hi, need to submit a 4000 words essay on the topic Case study reflection 2 pages per case 8 total.
tudy of metformin-associated lactic acidosis-MALA, in which the interactions of drug that is, orlistat in the long run and cimetidine in the short run, may have triggered the woman’s condition (British Medical Association, 1988, pp56-87).
The case involves a 59-year-old woman having had diabetes type 2 for 14 years, presented a history of 3 months of unclear abdominal pain and 4-5 daily loose movements of bowel. Her condition had worsened for over 4 days before her admission to the hospital. On the admission day, she exhibited signs of weakness, dizziness, and blurred vision. In addition, her husband had observed inaudible speech and an abridged level of consciousness (Ehrman, 2009, pp234-345).
When the diagnosis of metformin-associated lactic acidosis with cardiovascular collapse and acute prerenal renal failure was made, it was discovered that she needed She required a vigorous rehydration, infusion of sodium bicarbonate, support of inotropic, and the therapy of renal replacement. Empirically, all cultures of blood, urine, and feces were sterile. Three years later she was dialysis independent and the stability of became real having a creatinine of 250 μmol/l.
The study aims at answering the question of what initiates MALA in patients who previously had normal renal functions. Though the approach of handling this condition is unknown, the available options have been supportive and usually focus stopping the drug, correcting the acidosis and treating the coexisting conditions which in most instances are renal impairment. The therapy of renal impairment eliminates lactate and metformin from the blood. Metformin is absorbed comparatively rapidly in the intestines, and is not metabolized. And 90% of the drug is removed through glomerular filtration and secretions in the tubules. It has a half-life of 1.5-5 hours (Dong, 2006, pp34-45). When compared with phenformin, it yields a negligible increase in producing lactate, which seems to be past the extra hepatic
