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QUESTION

How many chiral centers are there in cholesterol?

There are eight chiral centres in cholesterol.

The structure of cholesterol with its numbering is shown below.

(Adapted from en.wikipedia.org)

Remember that bond-line structures don't show the hydrogen atoms that are attached to carbon.

There is no internal plane of symmetry, so every carbon atom is different.

Each chiral carbon must have four different groups.

I have circled the chiral centres in the molecule

The eight chiral centres (with the attached groups) are:

  1. ##"C3 (OH, C4, C2, H)"##
  2. ##"C8 (C9, C14, C7, H)"##
  3. ##"C9 (C10, C8, C11, H)"##
  4. ##"C10 (C5, C9, C1, C19)"##
  5. ##"C13 (C14, C17, C12, C18)"##
  6. ##"C14 (C13, C8, C15, H)"##
  7. ##"C17 (C13, C20, C16, H)"##
  8. ##"C20 (C17, C22, C21, H)"##
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