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I will pay for the following article Relationship between Mechanics and Drug Binding. The work is to be 5 pages with three to five sources, with in-text citations and a reference page.

I will pay for the following article Relationship between Mechanics and Drug Binding. The work is to be 5 pages with three to five sources, with in-text citations and a reference page.

It is projected that quantum mechanics continue growing in all the stages of Computer-assisted drug design. Though, a wide sampling of the conformational treatment of solution and space of macro-molecules is still the limiting factor for the wide use of Quantum mechanics in drug binding.

Accurate models for calculating the binding free energy between proteins and small molecules are required for drug design and development. The growing popularity of QM techniques in Computer-Assisted drug design is not only a consequence of increasing computing power, but it is also because of the first principle nature of quantum mechanics. For instance, quantum mechanics calculations were carried out to examine differences in binding affinities after modification of &nbsp.&nbsp.–CH2 βˆ’ linkers into carbonyls.

The routine application of quantum mechanics in all drug binding phases is the rational step in drug design. The first principles of quantum mechanics allow it to systematically improve the accuracy of the descriptions of trug molecules interactions' characteristics. The design and development of new drugs is a complex and expensive enterprise, which requires the interplay of several scientific facets through integrated multi-disciplinary teams. The key roles of computational chemistry within this multi-disciplinary team have become firmly established. Metric points to the measurable effect of computer-aided medicine design across a discovery timeline. More recently, computational drug chemists have a wide range of chemical databases, informatics and silicon tools at their disposal. The available design tools include pipelining tools, advanced molecular graphics, sand ub-structure searching tools, used to derive quantitative structure-activity relationships, statistical packages, pharmacophore-based analysis, and receptor-ligand binding tools.

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