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Makers of generic drugs must show that they do not differ significantly from the "reference" drugsthey imitate. one aspect in which drugs might differ is their extent of absorption in the blood.the da
Makers of generic drugs must show that they do not differ significantly from the "reference" drugsthey imitate. one aspect in which drugs might differ is their extent of absorption in the blood.the data in the file drugabsorption.xls was taken from 20 healthy nonsmoking male subjects forone pair of drugs. this is a matched pairs design. numbers 1 to 20 were assigned at random tothe subjects. subjects 1 to 10 received the generic drug first, and subjects 11 to 20 received thereference drug first. in all cases, a washout period separated the two drugs so that the first haddisappeared from the blood before the subject took the second.1.make a histogram of the differences (use class size of 500) to see that they appearto follow a reasonably normal distribution with no outliers.2.consider the question: do the drugs differ significantly in absorption? state thenull and alternative hypotheses relative to this question.3.find thettest statistic.4.what is thep-value for yourt?5.do the drugs differ significantly in absorption at significance levelĪ±= 0.05?
