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Need help with my writing homework on Molecular Mechanism of Antibiotic Resistance in Escherichia Coli. Write a 2000 word paper answering;
Need help with my writing homework on Molecular Mechanism of Antibiotic Resistance in Escherichia Coli. Write a 2000 word paper answering; Fortunately, the genetic sequence of E. coli is already established and safely stored inaccessible archives. This is irrespective of the plasticity experienced while sequencing the DNA of E. coli. .
The quantification of the mechanism behind the resistance calls for the isolation of E. coli strains that exhibit this form of resistance. Due to the wide range of antibiotics available for the fight against the spread of the bacteria, it is vital to focus on strains that exhibit multiple resistances. This is also of merit in a rather different perception in that. it can facilitate the development of antibiotics that encompass solutions to different targets. This helps in the improvement of their therapeutic efficacy.
In this regard, a central region of focus falls under the integrons (these are genetic elements able to target and rearrange ORFs embedded in gene cassette units and change them to functional genes by ensuring their proper expression). This is with regards to their heightened presence in organisms exhibiting multiple antibiotic resistances. They were originally associated with gram-negative bacteria. Progressively the analysis of strategic loci may be of great essence in the quantification of the avenues followed towards the establishment of resistance in E. coli. Such a locus is the mar locus (Michael, 2007). On reference is that rapid mutations experienced in the mentioned locus. that eventuate into the alteration of the coding sequence, hence aberration of the protein sequence produced.
Apparently, the development of resistance towards a given antibiotic is based on two broad mechanisms. They include the development of a mutated genetic sequence at the DNA level and the horizontal line gene transfer (also .termed lateral gene transfer). This simply refers to the accumulation of various mutations via a systematic process. where the central microbe, in this case, .E. coli, accumulates the necessary mutation via prokaryotic DNA absorption mechanisms. This includes mechanisms such as transduction, transformation, gene transfer agents (found in alphaproteobacteria), or conjugation. .
