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Patient S ex Cl inic al S tatu s H I V R is k Fac to r A F AI DS No C M CD4 lt; 20 0 / m m 3 U nk no w n F CD4 lt; 50 0 / m m 3 B D E F G F M M M...

A dentist showed symptoms of HIV infection in late 1986, and was diagnosed with AIDS in 1987. At the time of the AIDS diagnosis, AZT therapy was begun, discontinued for a short period in late 1987, then restarted and continued until his practice closed in 1989. All of the dentist's employees, including the dental hygienists, tested negative for HIV antibodies.The dentist wrote an open letter to his former patients, which prompted 591 persons to be tested for HIV antibodies. The following list summarizes the seropositive individuals. See Data on attachment.1. Analyses of DNA and amino acid sequences from HIV isolated from the patients strongly suggest that five of the patients were infected by the dentist. Which two were not? How did you arrive at your conclusion?2. How can transmission of HIV and hepatitis B by health-care workers be prevented?

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