Predict how the following environmental changes will affect the pKa of a histidine residue in a protein:

Predict how the following environmental changes will affect the pKa of a histidine residue in a protein:a) an aspartic acid residue in the same protein is brought into close proximityb) the histidine side chain shifts from the outside of the protein to a nonpolar site insidec) an arginine residue in the same protein, that was close, moves awayIn each case, will the pKa will go up, down, or remain the same? Explain.

Predict how the following environmental changes will affect the pKa of a histidine residue ina protein:a) an aspartic acid residue in the same protein is brought into close proximityAns. pKa...