Sickle-cell anemia is caused by a genetic defect that substitutes valine for glutamic acid at one position in two of the four chains of the...

. Sickle-cell anemia is caused by a genetic defect that substitutes valine for glutamic acid at one position in two of the four chains of the hemoglobin protein. The result is a decrease in the water solubility of hemoglobin. Examine the structures of valine and glutamic acid and explain why this might be so.