Sickle-cell anemia is caused by a mutation in the -globin gene.

1. Sickle-cell anemia is caused by a mutation in the -globin gene. Heterozygotes for the Hbs disease allele have some protection from malaria relative to wild-type, but Hbs homozygotes rarely live to produce offspring. 50 individuals homozygous for the normal (non-disease) allele produced a total of 47 children. 50 heterozygous individuals produced a total of 55 children. 50 Hbs homozygous individuals produced a total of 0 children. What is the average fitness per individual of the heterozygotes? What is the relative fitness of the homozygous normal individuals?