The CYP209* 3 variant is found in exon 7. The normal (reference) nucleotide at this position is an A. The *3 variant refers to the presence of a C...

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The CYP209* 3 variant is found in exon 7. The normal (reference) nucleotide at this position is an A. The *3 variantrefers to the presence of a C instead of an A in this position. This change results in an 80-90% decrease in enzyme ac-tivity. Both of these variants decrease the body's ability to metabolize warfarin. If the body cannot metabolize warfarinas well, warfarin will stay in the body longer. Therefore, people with these variants need lower doses of warfarin.6. Another variant is found in the middle of the first intron of the CYP2C9 gene. The reference value is a T and thevariant is a C variant. Would this variant change an amino acid? Why?7. Of the three variants mentioned above, 23andMe only tests for the CYP209*2 and *3 variants, but not the variantin the intron. Why?Interestingly, as a member of the cytochrome P450 gene family, CYP2C9 is involved in metabolizing a large number ofmedications such as NSAIDs (aspirin, ibuprofen, naproxen), some seizure medications, and some diabetic medications,