The prefrontal lobotomy was widely used in the 1940s and 1950s. It was based on observations of one chimpanzee, whose behavior changed after receiving bilateral lesions to her prefrontal lobe. Largely

The prefrontal lobotomy was widely used in the 1940s and 1950s. It was based on observations of one chimpanzee, whose behavior changed after receiving bilateral lesions to her prefrontal lobe. Largely on this evidence, doctors performed prefrontal lobotomies on human patients who suffered from psychiatric disorders to calm them down. There were side effects and this therapy often did not provide the expected benefits for the patients. What was wrong with the progression from a few primates to widespread use in humans? What questions should have been asked before the technique was used in people?