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The time point at which Cmax is reached is tmax. tmax depends on:
Q1. The time point at which Cmax is reached is tmax. tmax depends on:
a) The administered dose of the drug
b) The rate of absorption
c) The rate of elimination
d) The magnitude of the first pass effect
Q2. A painkiller (half life 3 hours) given in a dose of 100 mg gives a relief of the pain in a patient for 5 hours. At a dose of 200 mg the painkiller will be effective in this patient for 10 hours:
a) correct
b) incorrect.
Explain why.
Q3. In the liver most drugs are converted into metabolites. The lipophilicity of these metabolites is usually lower than that of the drug itself (the parent compound). This results in a rapid excretion of the metabolite from the body. This is caused by:
a) The smaller volume of distribution of the metabolite compared to that of the parent compound
b) The increased renal clearance of the drug compared to that of the parent compound
c) both a and b
