The U.S. Constitution is based on a particular view of human nature ( self-interest). How did that view influence the structure of the government?

The U.S. Constitution is based on a particular view of human nature ( self-interest). How did that view influence the structure of the government? How were the weaknesses of human nature exploited to safeguard against abuses of government power?

if you guys can please make the response of a page to this question , because im trying to get the most knowledge and have to study for a test from it thank you. :)