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We identified your fingerprint at one locus, D1S80, with 25 known alleles.
We identified your fingerprint at one locus, D1S80, with 25known alleles. Within the human genome, manyshort tandem repeat (STR) regions have been identified. Tens of thousands of STR regions exist withinexons and introns of various genes. About half of these are highly polymorphic, that is, the number of STRsis highly variable. STRs consist of athree to seven base pair motif that is repeated a variable number of times in atandem array.
Consideralso the following three STRs, used most frequently by crime labs, and answerthe following questions about your experiment and about crime lab DNAfingerprinting. The first one (CSF1PO)is located on chromosome arm 5q and the number of repeats varies between 6 and15 (i.e. there are ten known alleles). These alleles lie within a proto-oncogene. A second STR (TPOX) lies within the thyroidperoxidase gene on chromosome arm 2p and the repeat number varies between 6 and12 repeats (i.e. there are seven known alleles). Finally, a third STR site (THO1) is locatedon 11p and the number of repeats varies between 5 and 11 (but also includes a9.3 repeat allele caused by a truncated repeat, for 8 known alleles).
- Howmany different allelic combinations (i.e. genotypes) could exist inthe human population for the D1S80 locus? (Consider the number of different homozygous and heterozygousgenotypes that could occur with the 25 known alleles.) Showyour calculations here and on the remaining problems!
- Howmany different allelic combinations could exist in the human populationsfor the
- CS1POlocus?
- TPOXlocus?
- THO1locus?
- Ifeach combination occurred with equal frequency, what is the probabilitythat a randomly-chosen person would carry the same genotype as you at
- CS1POlocus?
- TPOXlocus?
- THO1locus?
- ForDNA fingerprinting, crime labs identify a person’s DNA fingerprint at eachof the 3 loci: CSF1PO, TPOX and THO1. If each combination occurred with equal frequency, what is theprobability that a randomly-chosen person would carry the same genotype asyou at all three loci?
- Howmany people in the would be expected to share a particular genotype forthese 3 loci
a. inthe entire world (population 7 billion)?
b. inNorth Carolina (population 10 million)?
