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What is the MOA of Losartan?

 What is the MOA of Losartan?

Blocks the vasoconstrictor and aldosterone-secretion effects of Angiotensin II to the AT1 receptors in the smooth muscles

Blocks the conversion of angiotensin I to angiotensin II to prevent vasoconstriction

Inhibits reabsorption of sodium and chloride ions in the loop of Henle

Increases the osmolarity of the renal tubular fluid and prevents reabsorption of water

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