What was the effect of the Indian Removal Act of 1830?

The Indian Removal Act of 1830 resulted in the mass migrations of many Native Americans in North America.

The Indian Removal Act of 1830 was signed into effect by President Jackson, which allowed Native Americans to settle in land within state borders in exchange for unsettled land west of the Mississippi. Many Native American tribes reacted peacefully, but many reacted violently. The tribes reacted this way because they believed the land had religious significance. Because of this, some tribes were unwilling to move. One significant example is the Cherokee tribe, who was forcibly led to move from their homelands by US soldiers. Over 4000 Cherokee Native Americans died on this trail, which is now known as the "Trail of Tears." Source: (https://www.loc.gov/rr/program/bib/ourdocs/Indian.html)