Which of the following are true of pharmacokinetic (PK) tolerance:

Which of the following are true of pharmacokinetic (PK) tolerance:

a) A drug produces effects that reduce its own bio-availability through liver enzyme induction

b) The peak effect and duration of action of a drug are increased as a result of this tolerance

c) There is a greater concentration of drug at target site due to increased bioavailability

d) B and C