Which of the following skin structure was most likely the site of action of the prescribed drug?

Which of the following skin structure was most likely the site of action of the prescribed drug?A 31-year-old man presented to his physician with an annular lesion with raised borders in his left hand. Microscopic examination of skin scrapings revealed branching hyphae. The diagnosis of tinea manus was made and the patient was prescribed an appropriated oral treatment.

A. Stratum basale

B. Stratum spinosum

C. Stratum corneum

D. Pigment layer

E. Hair follicle

F. Hair shaft