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Why was bretylium tosylate discontinued?
The American Heart Association removed bretylium tosylate from their guidelines because of "ongoing supply problems".
The manufacturers could not provide a reliable supply of the drug.
The structure of bretylium tosylate [(o-bromobenzyl)ethyldimethylammoniump-toluenesulfonate] is
You can probably imagine the difficulty of carrying out an electrophilic aromatic substitution that puts two bulky groups next to each other on a benzene ring.
If you can devise an efficient synthesis of bretylium tosylate for the pharmaceutical companies, you will become a rich person.
