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Write 15 pages with APA style on The aim of the project is to find a Competitive inhibitor which will inhibit the methylation of Protein phosphate 2A (PP2A) Via LCMT-1.
Write 15 pages with APA style on The aim of the project is to find a Competitive inhibitor which will inhibit the methylation of Protein phosphate 2A (PP2A) Via LCMT-1. This means that the methylation of PP2A may be an important regulatory mechanism on the condition that the PP2A methylation is tightly regulated.
Tamanoi and Clarke (2006, p. 316) further presents that there are two main levels of regulation of the PP2A. This is may be achieved either through demethylating enzyme LCMT1 or PME-1 or the regulation at the C-terminal tail of PP2AC site (Tamanoi and Clarke, 2006, p. 316). Furthermore, they advance that the methylation of PP2A can also be regulated or deregulated by certain diseases(Sheng 2013). Seshacharyulu, Pandey, Datta and Batra (2013, p.9) elaborates that PP2A serves to regulate the function by dephosphorylating numerous important cellular molecules such as the p53 and Akt. The PP2A is significant in critical cellular processes including signal transduction, proliferation and apoptosis.
PP2A is structurally multifarious made up of catalytic, support and regulatory subunits. The support and catalytic sub-units of the PP2A comprise of two major isoforms, whereas the regulatory sub-unit has four distinct families of different isoforms. Of these sub-units, the regulatory sub-unit is considered the most diverse in terms of spatial and temporal specificity.
The PP2A usually undergoes certain post-translational changes such as methylation and phosphorylation that serve to regulate the enzymatic activity of PP2A. Certain somatic alterations, mutations and aberrant expression of the PP2A support and regulatory sub-units have been common in a variety of malignancies in humans including skin, breast and lung cancers. This demonstrates that the role of PP2A as a tumor suppressor (Seshacharyulu et.al 2013). A group of heterogeneous genes encode the individual subunits of the enzyme. This gives rise to a multitude of various PP2A holoenzyme complexes (Schönthal 2013, p.2).