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Write 3 page essay on the topic Scleroderma From the Immunology Stance.Download file to see previous pages... Patients with scleroderma may have antibodies against topoisomerase I, RNA polymerases, ce
Write 3 page essay on the topic Scleroderma From the Immunology Stance.
Download file to see previous pages...Patients with scleroderma may have antibodies against topoisomerase I, RNA polymerases, centromere proteins B &. C, B23, Th/To-RNP, PM/Scl, U1-RNP or U3 RNPs (including fibrillarin). Amongst these antibodies, anti-topoisomerase I antibodies are seen most frequently. The presence of this antibody is associated with interstitial pulmonary fibrosis, cardiac involvement, and cancer. Severe skin involvement and renal crisis is associated with anti-RNA polymerase III antibodies, and anti-fibrillarin antibodies associate with primary pulmonary arterial hypertension and involvement of cardiac and skeletal muscle. (Harris ML, Rosen A.)
Antifibrillarin, is a nucleolar autoantibody, and serves as a marker for severe SSc (especially in blacks and males). “This antibody is associated with a unique HLA haplotype, as well as with combinations of certain HLA-DQB1 alleles”(Arnett FC, Reveille JD, Goldstein R, et al., 1996). “Patients with CREST syndrome (calcinosis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, telangiectasia), or limited SSc, have antibodies against centromere proteins or Th/To RNPs. The Th/To antigen, although rare, associates with hypothyroidism and small bowel involvement”(Harris ML, Rosen A).
These include anti-Th/To antibodies, B23, and U3-RNP. Anti-Th/To antibodies are seen in a subset of patients with limited skin disease but significant lung disease. B23, has a strong association with pulmonary hypertension and lung disease.
