Article 1 Living well with chronic pain: a 12-month randomized controlled trial revealing impact from the digital pain self-management program EPIOLinks to an external site. Nes, L. S., Børøsund, E.,

Article 1Living well with chronic pain: a 12-month randomized controlled trial revealing impact from the digital pain self-management program EPIOLinks to an external site.

Nes, L. S., Børøsund, E., Varsi, C., Eide, H., Waxenberg, L. B., Weiss, K. E., Morrison, E. J., Støle, H. S., Kristjansdottir, Ó. B., Bostrøm, K., Strand, E. B., Hagen, M. C. S., Stubhaug, A., & Schreurs, K. M. (2024). Living well with chronic pain: a 12-month randomized controlled trial revealing impact from the digital pain self-management program EPIO. PAIN Reports, 9(4), e1174. https://doi.org/10.1097/pr9.0000000000001174

Article 2

Effect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder ArthroscopyLinks to an external site.

Duong, A., Ponniah, A. K., VanDeCapelle, C., Mossuto, F., Romeril, E., Phillips, S., Johal, H., Al-Asiri, J., Tushinski, D., Wood, T. J., Peterson, D., Denkers, M., Adili, A., Khanna, V., Moro, J., Kashir, I., Mwakijele, G., Shing, D. Y., Gazendam, A., . . . Ayeni, O. R. (2022). Effect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder Arthroscopy. JAMA, 328(13), 1326. https://doi.org/10.1001/jama.2022.16844

                                                                      Question 1: 

Use one of the articles and explain an associated concept as utilized in the study:

1. Research design
2. Sample size
3. Validity, external/internal validity
4. Subject selection, randomization and blinding
5. Ethical considerations
6. Generalizability                                                          Question 2                                                                                                                        Select and post one outside article containing a clinical trial currently underway in the United States. The randomized clinical trial can be in any of the four stages.  Provide a brief discussion of your thoughts about the RCT from the concepts you have mastered this week.

                                                                Question 3

A case-control study is characterized by all of the following except:

1. It is relatively inexpensive compared with most other epidemiologic study designs.
2. Patients with the disease (cases) are compared with persons without the disease (controls)
3. Incidence rates may be computed directly.
4. Assessment of past exposure may be biased.
5. Definition of cases may be difficult

 Give reasons why the wrong answers are wrong and why the correct answer is right.  If doing a mathematical problem, please show your work as this is helpful for all.

3 or more references within 5 years.