Compose a 1500 words essay on Osteogenesis Imperfecta. Needs to be plagiarism free!Download file to see previous pages... The bigger amino acid network leads to the formation of steric obstruction tha

Compose a 1500 words essay on Osteogenesis Imperfecta. Needs to be plagiarism free!

The bigger amino acid network leads to the formation of steric obstruction that creates a swelling in the collagen structure which consequently affects the contact of molecules with one another as well as the nanomechanics of molecules. As a result of this reaction the body responds by dissolving the deformed structure of collagen because if the body does not do so, the interaction existing between the collagen fibers and hydroxyapatite particles that form the bone is changed making them weak and brittle. Another reason that is suggested for the occurrence of this disease is the state of stress at the collagen fibers. when the stress level changes at the points of mutation, where the bigger cut off pressures lead to rapid failing of fibrils even at medium level. There are a lot of reasons all related to the genes that lead to osteogenesis imperfecta. This disease is generally perceived as hereditary however this is not the case. There are eight different types of osteogenesis imperfecta, most common being Type 1. ...

Hearing impairment in infants Slight protuberance of the eyes Type II The quality as well as the quantity of collagen in this type is poor. Most patients suffering from this type of osteogenesis imperfecta die in the initial years of life due to respiratory breakdown or cerebral hemorrhage. The lungs are underdeveloped due to which the patients face respiratory problems. Deformation of bones and small physique Type II is further classified into type IIA, type IIB and type IIC. Type III The quantity if collagen is sufficient but it is not of the required quality. The deformity of bones is such that sometimes they break eve before birth. Possibility of respiratory problems Short physique, bending of the spinal cord and in some cases the shape of rib cage is spiral Joints are loosened The tone of muscles in the arms and legs is of poor quality Discoloration of sclera which turns it form normal white to blue Hearing problems in early ages of infancy Type IV The quantity of collagen is sufficient but quality is not up to the mark. This type is very much similar to Type I as far as the classification is concerned. The fracture of bones starts in the teenage years Rib cage is barrel shaped which leads to deformation of lungs consequently resulting in respiratory problems. The deformity of bone is mild to medium level. Hearing loss starts from a very early age. Type V This has the same clinical characteristics as that of type IV with interconnected appearance of bones being the basic distinguishing factor. Type VI It has the same clinical characteristics as that of type IV. This stage is distinguished by the fish like appearance of the bones.