Waiting for answer This question has not been answered yet. You can hire a professional tutor to get the answer.

QUESTION

Hello, I am looking for someone to write an article on Genetic Diseases: Hemophilia A. It needs to be at least 1500 words.

Hello, I am looking for someone to write an article on Genetic Diseases: Hemophilia A. It needs to be at least 1500 words. These diseases, especially new occurring ones, can be caused by inherited genetic conditions in some individuals, or by mutations in others. However, this is mainly so by way of environmental causal factors in a majority of populations (Zaiden, 2013). Different individuals do react differently to the presence or absence of such disorders. This affects the individual by whether, to what extent, and when, he/she will actually suffer from the disorder. To be noted is that this is usually influenced by the prevailing environmental factors present, and/ or the affected individual’s development.

As Bowen (2002) provides, Hemophilia A is a genetic disorder, which is primarily caused by the deficiency in factor VIII, essential for clotting, quick, and timely wound recovery. A negative effect is that there is an increase in bleeding, affecting mainly the males of the human species. The biggest percentage of this disorder is usually inherited, in the form of an X-linked trait that is recessive. However, a minor percentage of these cases do exist, arising from mutations, which occur spontaneously. Being an X-linked recessive trait, it is thus prevalent in males, as well as females who are homozygous in nature (Bowen, 2002:4).

This, however, does not mean that the same type, A, and at times B, do not occur in females who are heterozygous. This is true especially in the case of X-inactivation, thus the recommendation that all recognized potential carriers of factor VIII and IX be examined. This is especially prior to cases of surgery, and in the event of bleeding, that is considered clinically significant (Bowen, 2002:6). A small percentage of 5-10% of those affected with this disorder are usually impacted because of their bodies making a version of the factor VIII protein, which is dysfunctional (qualitative deficiency).

However, the larger majority of those affected are influenced by their bodies’ insufficient production of factor VIII (quantitative deficiency). Severe deficiency is defined as being less than 1% activity of factor VIII (11). 45-50% of those affected do have the same mutation with the case of an inversion, within the factor VIII gene resulting in the total elimination of the production process of proteins. Thus, genetic tests are most recommended when testing family relations, in the context of known cases of the disorder. It is approximated that 30% of all patient cases do not contract the ailment from genetic makeup, but rather as a cause of new mutations (Bowen, 2002:17).&nbsp.&nbsp.

Show more
LEARN MORE EFFECTIVELY AND GET BETTER GRADES!
Ask a Question