Hello, I am looking for someone to write an essay on Pectin As a Natural Excipient in Tablet Formulations. It needs to be at least 1500 words.Download file to see previous pages... Using a typical pla

Hello, I am looking for someone to write an essay on Pectin As a Natural Excipient in Tablet Formulations. It needs to be at least 1500 words.

Using a typical plant cell wall as an example, pectin has both in-muro and out-of-muro properties that make it possible to control cell wall integrity and porosity and give plants protection against phytopathogens (Bhattacharjee and Timell, 2005). Moreover, apart from the fact that pectin has functional roles in plant morphology, growth and general development, it also has been found to be highly defensive for the plant cell wall as it acts as a gelling and stabilising polymer agent (Aspinall and Fanous, 1984).

Indeed, the aim of the proposed project is directly related to the property of pectin that makes it act as a gelling and stabilising polymer in a number of food and specialty products (Vincken et al., 2003. Mohnen, 2008). It is the aim of the project to investigate how this property of pectin can make it act as a natural excipient in tablet formulations. Using dried mango fruit peels as sources of extracted pectin, the researcher seeks to investigate the binding property in such pectin and how it would aid in tablet formulation, by use of sodium salicylate as a drug model. On the whole, the research will be carried out in a manner that formulates four major different batches of tablets using different weights of pectins such as 10, 20 30 and 40 mg. The binding property of pectin that will be recorded in the sodium salicylate will then be compared to other models of binding agents, particularly starch. Eventually, testing of the binding property will be done with pectin as an experimental agent and starch as a control agent (Malviya, Srivastava, Bansal and Sharma, 2010). Background literature The research problem being identified is not the first of its kind in the field of pharmacological studies. There have been a number of researchers who have had similar projects related directly to the proposed study. Yapo (2011) focused on the different co-polymer blocks available in complex pectin. In the study, it was found that there are four main co-polymer blocks, which are: unsubstituted homogalacturonan (HGs), otherwise known as linear galacturonan, which has been found to come in two major forms, i.e. low methyl-esterified HG and high methyl-esterified HG (Steffe, 1996). rhamnogalacturonan-I (RG-I), which has been found to be branched and compositionally heterogeneous and having ?-D-GalpA, NS residues such as ?-L-Rhap, ?-L-Araf and ?-D-Galp (Willats et al. 2001). rhamnogalacturonan-II (RG-II), which happens to be the most widespread form of SGs in plant cell walls (Beldman et al., 2001). and xylogalacturonan XGA), which can be isolated using chemical processes that include mild alkaline hydrolysis (Matsunaga et al., 2004). Generally, the study by Yapo (2011) is relevant to this research because it will help in knowing the various size-exclusion chromatography (SEC) elution profiles of the co-polymers that exist in the cell walls of pectin (Le Goff et al., 2001. O’Donoghue and Somerfield, 2008). In the diagram below, there is an example of a pectin source, such as mango, manifested when deesterified through endo-PG-digested acid extraction. Source: Yapo (2011). In another related study, Fissore, Rojas, Gerschenson and Williams (2012) looked into the characterisation and functional properties of pectin.