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Need an argumentative essay on Clinical and Metabolic Consequences of Type 1 and 2 Diabetes. Needs to be 14 pages. Please no plagiarism.The range of characteristics of type 2 diabetes has been describ
Need an argumentative essay on Clinical and Metabolic Consequences of Type 1 and 2 Diabetes. Needs to be 14 pages. Please no plagiarism.
The range of characteristics of type 2 diabetes has been described as “predominantly insulin resistance with relative insulin deficiency to predominantly an insulin secretory defect with insulin resistance” (American Diabetes Association, 2006). Some studies have suggested an associated reduction in β cell mass due to increased apoptosis in type 2 diabetes (Butler et al., 2003). However, both types of diabetes are believed to share a common genetic etiology, and clinical evidence also indicates a marked overlap between these two diabetic conditions. For instance, anti-islet cell antibodies, elevated circulating cytokines and chemokines typically associated with type 1 diabetes have been observed in many patients with type 2 diabetes. Similarly, obesity, which is commonly linked to insulin resistance and type 2 diabetes, has been seen to correlate strongly with type 1 diabetes as well (Donath and Halban, 2004). Worldwide, type 2 diabetes has assumed epidemic proportions. The projected estimate of increase is 221 million diabetic people in 2010 from the 151 million diagnosed with diabetes in 2000 and expected to rise further to 324 million by 2025 (Zimmet et al., 2001).
Type 2 diabetes is generally associated with a condition known as metabolic syndrome. The Adult Treatment Panel III (ATP III, 2001) Report guidelines have suggested the working definition of the metabolic syndrome as the presence of at least 3 of the following features: abdominal obesity, atherogenic dyslipidemia or elevated triglycerides, reduced levels of HDL cholesterol, small low-density lipoprotein [LDL] particles, high blood pressure, insulin resistance and high fasting glucose, and prothrombotic and proinflammatory states (Reaven, 1988).
