Need an argumentative essay on Critically discuss how advances in the understanding of the pathogenesis of paroxysmal nocturnal haemoglobinuria. Needs to be 5 pages. Please no plagiarism.Download file

Need an argumentative essay on Critically discuss how advances in the understanding of the pathogenesis of paroxysmal nocturnal haemoglobinuria. Needs to be 5 pages. Please no plagiarism.

The clinical hallmark of paroxysmal nocturnal hemoglobinuria or PNH is chronic intravascular hemolysis that is a consequence of unregulated activation of the alternative pathway of complement or APC (Lindorfer et al 2010).&nbsp.Intravascular hemolysis can be inhibited in patients by treatment with eculizumab, a monoclonal antibody that binds complement C5 thereby preventing formation of the cytolytic membrane attack complex of complement (Lindorfer et al 2010). Many studies have been conducted to identify the effect of the advances in understanding the pathogenesis of paroxysmal nocturnal hemoglobinuria or PNH to its diagnosis, treatment and prognosis. Likewise, a variety of articles also analyzed the aforementioned subject matter. This paper endeavors to tackle the definition and etiology of Paroxysmal Nocturnal Hemoglobinuria or PNH. in particular, this paper will focus on the developments made in gaining perception of the pathogenesis of paroxysmal nocturnal hemoglobinuria and its impact to the diagnosis, treatment and prognosis of this condition employing the use of several journal articles as theoretical basis. Literature Review The complement system provides critical immunoprotective and immunoregulatory functions but uncontrolled complement activation can lead to severe pathology (Rother et al 2007).