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What are the methods and techniques used to predict if genetic mutation is pathogenic or neutral. or in the other words, what are the bioinformatics tools or machine learning that are used. Also, I wa

What are the methods and techniques used to predict if genetic mutation is pathogenic or neutral. or in the other words, what are the bioinformatics tools or machine learning that are used. Also, I want to write a paragraph that describe the mutation classification. 

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