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Write 15 page essay on the topic The Healing Effects on Tendons or Ligaments.Download file to see previous pages... Most of the studies used between 6 and 10 subjects or tendon sets. : Studies showed
Write 15 page essay on the topic The Healing Effects on Tendons or Ligaments.
Download file to see previous pages...Most of the studies used between 6 and 10 subjects or tendon sets. : Studies showed positive results on tendon and ligament healing with IGF-1.
Conclusion: All of the studies indicate positive results in the healing process for tendons as well as ligaments. There are still many unknowns. The healing effect has been shown but not clearly in live tendons or human tendons. There is also a continued need for further well-defined study in the form of human clinical trials with a larger number of participants. These trials should be specific to tendon and ligament injury.
Tendon and ligament injury can be devastating. Healing can be long and arduous and even when healed there may be scar tissue that prevents full use of the tendon or ligament, preventing the patient from being able to support the amount of loading in that area that was allowed before. This review of research is to determine if IGF-1 is able to improve the method of healing in such a way that the process is improved and faster providing for less scar tissue and allowing better use of the tendon or ligament after healing. IGF-1 is a natural molecular structure similar to insulin (insulin-like-growth-factor-1). As a natural growth hormone, it is produced by the body allowing children to grow. It consists of a number of interconnected amino acids that make up a single chain and that chain is called IGF-1. The primary purpose of this hormone is to stimulate cell growth and many kinds of cells are affected. The interest of this research is to determine if the cells of tendons and ligaments are affected in such a positive manner to allow those cells to be repaired.
Tendons have shown an ability to adapt to changes in mechanical loading and injury. They consist of what is seen as a dense extracellular matrix that has collagen as the major protein. IGF-1 is one substance that is promising in the mediation of the effects of the tendon to produce collagen. If collagen is effectively produced at the time of the tendon or ligament injury, it is supposed that the tendon might heal better. IGF-1 has been shown to be highly effective during the inflammatory phase of a healing process in studies using animal and human tendons but what about the healing phase It also has shown to aid in the proliferation and migration of fibroblasts and to subsequently increase collagen production. [1] Studies with rats, such as the one done by Scott (2008), shows that IGF-1 may be a potent stimulator that is available for many kinds of tissues. In increasing the amount of collagen produced, it adapts itself well to the possibility of healing without scaring.
The principles of tendon healing are somewhat different than the healing of other tissues. Most tendons have the ability to heal themselves but when they do there is a great deal of scar tissue that leads to the tendon being less effective than prior to the injury.
