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Write a 5 page essay on Where are the nestin-labelled stem cells in the hair follicle.Download file to see previous pages... Many cells stem from them. The cells have the ability to renew themselves,
Write a 5 page essay on Where are the nestin-labelled stem cells in the hair follicle.
Download file to see previous pages...Many cells stem from them. The cells have the ability to renew themselves, generate daughter cells identical to their mothers and to create progeny that can differentiate to other cells (Kelly, 2007, p. 4). They are classified according to their origin. Those from the embryo for example are called embryonic stem cells. there are also adult stem cells and embryonic germ stem cells (Kelly, 2007, p. 4 and Bongso &. Lee, 2010, p. 2). Stem cells have three very important characteristics that differentiate them from other cells. These are. They are unspecialized cells They can be induced with special functions to become specialized cells and They have the ability to differentiate to specialized cells (Kelly, 2007, p. 5 and Grace &. National Academies Press, 2006). Because of these characteristics, stem cells are very important in reparative or regenerative medicine. Having the ability to produce specialized cells means they can be used to form specialized cells to replace the damaged ones. and being unspecialized also means they can be induced to form specialized cells for tissue repair or replacements (Kelly, 2007, p. 5 and Grace &. National Academies Press, 2006). Stem cell research is one of the most promising areas in basic research. Initial research involved the use of their regenerative ability to repair organs due to injury, but now there is increasing interest in what these cells can do in the pathogenesis of disease processes (Fong, 2007, p. 6). Knowledge and understanding of attributes and control of stem cells, enables scientists to understand human development and disease pathogenesis. Diseases like cancers are thought to be as a result of abnormal cell differentiation and proliferation. An understanding of cell proliferation in stem cells can help in finding out the causes of such cancers, preventive measures and their treatments (Murnaghan, 2010). It has been used in understanding birth defects and in cell therapies. Currently, stem cell research has reached a level where it is used to treat some cancers for example leukemia and other diseases where bone marrow transplants solve the problem. Other areas it is likely to help are. stroke, type I diabetes, Parkinson’s disease, spinal cord injuries, Alzheimer’s diseases and Retinal diseases (Murnaghan, 2010). A lot more is still going on and scientists are exploiting information available on stem cell research that can help treat or provide a solution to most of human diseases (Hoffman, 2007 and Steindler, 2007, p. 323). In this case, stem cells in the hair follicle have been found to be important and the aim of the research is to find where such stem cells are in the follicle. The reason for targeting nestin-labelled stem cells in the hair follicle is because of the relative accessibility of the tissue and the identified role of these stem cells in restoring nerve function and nerve regeneration (Hoffman, 2007 and Shastri, 2010, p. 63). Nestin-labelled Stem Cells The hair follicle has been found to be an easily accessible source of pluripotent adult stem cells (Shakhova &. Sommer, 2010, Hoffman, 2007). Nestin is a protein marker for neural stem cells. these markers are also expressed in the stem cells of hair follicle and the differentiated progeny of the follicle (Amoh et al, 2005 (a) and Hoffman, 2007). Because of this expression, nestin-labelled stem cells in the hair follicle could be an easily accessible source of such neural stem cells. Amoh, Li, Katsuoka and Hoffman (2005), found that stem cells from the hair follicle are pluripotent, primitive and have the capability of differentiating into diverse and multiple types of cells.
