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Provide a 3 pages analysis while answering the following question: Progesterone and TBI Treatment. Prepare this assignment according to the guidelines found in the APA Style Guide. An abstract is requ
Provide a 3 pages analysis while answering the following question: Progesterone and TBI Treatment. Prepare this assignment according to the guidelines found in the APA Style Guide. An abstract is required. This paper is a summary of Sayeed’s and Stein’s article and points out the research hypothesis, research methods, test results, and the main emphasis of the research. According to the article, the mechanisms induced by traumatic brain injuries include inflammation, necrosis, antioxidants, increased levels of anti-inflammatory cytokines, and antioxidants. The article points out several treatments for TBI that have undergone trial with little success. The treatments include Glucocorticoids, Corticosteroids, and magnesium sulphate, which were discontinued or terminated due to their side effects or propensity to increase death rates. The article points at several studies as well as preclinical trials that have shown the potential of progesterone, a hormone associated with female menstruation cycle, in reducing tissue damage, especially if administered at the acute stage of neuroinjury (Sayeed &. Stein, 2009). According to research carried out by Sayeed and Stein, progesterone and its metabolite referred to as allopegnanolone act by reducing cerebral oedema, excitotoxicity, and encourage myelination of injured axons as well as diminishing apoptosis. The above courses of action are vital in determining the rate and chances of recovery from traumatic brain injury and other ailments involving neuroinjury (Sayeed &. Stein, 2009).
